Motif ID: TLX1..3_NFIC{dimer}.p2

Z-value: 3.179


Transcription factors associated with TLX1..3_NFIC{dimer}.p2:

Gene SymbolEntrez IDGene Name
TLX1 3195 T-cell leukemia homeobox 1
TLX3 30012 T-cell leukemia homeobox 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TLX1chr10_+_102881050-0.401.3e-01Click!
TLX3chr5_+_1706688920.322.2e-01Click!


Activity profile for motif TLX1..3_NFIC{dimer}.p2.

activity profile for motif TLX1..3_NFIC{dimer}.p2


Sorted Z-values histogram for motif TLX1..3_NFIC{dimer}.p2

Sorted Z-values for motif TLX1..3_NFIC{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX1..3_NFIC{dimer}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_85066207 10.003 NM_013231
 FLRT2
fibronectin leucine rich transmembrane protein 2
chr14_+_85066265 9.748 FLRT2
fibronectin leucine rich transmembrane protein 2
chr21_+_32706615 7.534 NM_058187
 C21orf63
chromosome 21 open reading frame 63
chr3_-_11585264 6.921 NM_001128221
 VGLL4
vestigial like 4 (Drosophila)
chr15_-_38420414 6.618 NM_207380
 C15orf52
chromosome 15 open reading frame 52
chr5_+_38481392 6.343 NM_182801
 EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr8_-_13178327 6.286


chr7_+_22733626 5.997 IL6
interleukin 6 (interferon, beta 2)
chr10_+_17312654 5.962 VIM
vimentin
chr1_-_171441234 5.886 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr21_-_27139563 5.488 NM_006988
 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr7_+_102340579 5.454 NM_001031692
NM_005824
 LRRC17

leucine rich repeat containing 17

chr7_+_115952279 5.411 NM_001172895
 CAV1
caveolin 1, caveolae protein, 22kDa
chr5_+_150000394 5.398 NM_001109974
NM_007286
 SYNPO

synaptopodin

chr12_+_13240868 5.376 NM_001423
 EMP1
epithelial membrane protein 1
chr12_+_13240983 5.214 EMP1
epithelial membrane protein 1
chr12_+_13240987 5.198 EMP1
epithelial membrane protein 1
chr7_+_115952325 5.193 CAV1
caveolin 1, caveolae protein, 22kDa
chr2_-_192419896 5.185 SDPR
serum deprivation response
chrX_+_99785818 5.140 NM_014467
 SRPX2
sushi-repeat containing protein, X-linked 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
1.96 2.50e-02 GO:0072358 cardiovascular system development
1.96 2.50e-02 GO:0072359 circulatory system development
1.57 4.08e-03 GO:0009966 regulation of signal transduction
1.53 2.92e-03 GO:0023051 regulation of signaling
1.53 9.14e-03 GO:0009653 anatomical structure morphogenesis
1.44 6.92e-05 GO:0048731 system development
1.42 4.85e-02 GO:0048513 organ development
1.40 1.06e-04 GO:0048856 anatomical structure development
1.35 8.16e-04 GO:0007275 multicellular organismal development
1.34 3.90e-04 GO:0032502 developmental process
1.22 4.47e-02 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
2.42 3.48e-02 GO:0043025 neuronal cell body
2.23 4.68e-02 GO:0045177 apical part of cell
1.96 1.20e-02 GO:0043005 neuron projection
1.60 4.15e-03 GO:0044421 extracellular region part
1.34 2.90e-02 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
9.40 4.39e-02 GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity
3.65 2.24e-02 GO:0030165 PDZ domain binding
1.15 3.94e-02 GO:0005515 protein binding